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Test ID: 1p/19q FISH Testing
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1p/19q FISH Testing
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1p/19q FISH FFPE Test is to analyze oligodendroglioma brain tumors.
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Method name and description
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Interphase Fluorescence In Situ Hybridization (I-FISH) Study
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Clinical information
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The Interphase Fluorescence In Situ hybridization (I-FISH) test is utilized to analyze Oligodendroglioma brain tumors, shown in both low-grade and high-grade (anaplastic) oligodendrogliomas. To detect reaction for treatment of oligodendrogliomas.
This may be valuable in tumors with a complex "crossbreed" morphology, requiring separation from unadulterated astrocytoma to bolster the nearness of oligodendroglial differentiation/lineage. Unequivocally suggested when a conclusion of blended oligoastrocytomas is rendered.
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Specimen type / Specimen volume / Specimen container
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Specimen Type: Tissue Block/ Slide
Container/Tube: Slides from Tissue block
Specimen Volume: 1stained H&E slide - 4 unstained slides
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Storage and transport instructions
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Specimen Rejection Criteria
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Consistent with Diagnostic Genomic division policies.
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Factors affecting test performance and result interpretation
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The presence of 1p deletion and dual 1p and 19q deletion underpins a conclusion of oligodendroglioma, this may demonstrate that the quiet could react to chemotherapy and radiation treatment. The presence of pick up of chromosome 19 bolsters a conclusion of high-grade astrocytoma (glioblastoma multiforme). A negative result does not prohibit a determination of oligodendroglioma or high-grade astrocytoma.
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Turnaround time / Days and times test performed / Specimen retention time
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