|
Test ID: Teicoplanin Trough
|
|
Teicoplanin
|
|
Therapeutic Drug Monitoring Assay
|
|
Useful For
|
The test is useful in assessing serum concentrations of Teicoplanin. Monitoring trough levels is essential to ensure therapeutic efficacy by achieving sufficient concentration.
|
|
Method name and description
|
Teicoplanin assay is a homogeneous particle-enhanced turbidimetric immunoassay.
|
|
Clinical information
|
Teicoplanin (Targocid) is a bactericidal glycopeptide antibiotic that inhibits cell wall biosynthesis in Gram-positive bacteria. It is indicated for moderate to severe infections caused by susceptible staphylococci, streptococci, and enterococci.
Due to its high plasma protein binding and exceptionally long elimination half-life (up to 150 hours), fixed dosing regimens lead to significant inter-patient variability in serum concentrations. Therapeutic drug monitoring is essential to ensure trough concentrations are sufficient for efficacy while minimizing the risk of concentration-dependent toxicity, particularly during high-dose therapy.
Results must always be interpreted in conjunction with the patient's clinical presentation and other diagnostic findings.
|
|
Aliases
|
Teicoplanin
Teico
Therapeutic drug monitoring, TDM
|
|
|
Specimen type / Specimen volume / Specimen container
|
Specimen type: Serum, Plasma
Minimum volume of sample: 3 ml
Container: Serum: Plain tube (red or yellow)
Plasma: Lithium‑heparin tube
|
|
Collection instructions / Special Precautions / Timing of collection
|
Collect blood by standard venipuncture techniques as per specimen requirements. When processing samples in primary tubes (sample collection systems), follow the instructions of the tube manufacturer.
|
|
Storage and transport instructions
|
Storage:
7days at 2 – 8°C
28 days at ‑20 °C (± 5 °C)
Transport: For samples not reaching NCCCR within same day, Serum/Plasma should be transferred to a new plain tube to be stored and transported in 2-8°C
|
|
Specimen Rejection Criteria
|
Grossly hemolyzed, icteric and lipemic , wrong collection container, wrong transport temperature and insufficient sample
|
|
|
Biological reference intervals and clinical decision values
|
No reference intervals are applicable.
The target trough concentrations in adult patients are:
|
Indication
|
Target levels (mg/L)
|
|
Complicated skin and soft tissue infections, pneumonia, intra-abdominal infections and complicated urinary tract infections.
|
15-30
|
|
Bone and Joint Infections.
|
20-40
|
|
Infective endocarditis.
|
30-40
|
|
|
Turnaround time / Days and times test performed / Specimen retention time
|
Performance: Twice weekly
Turn-around time: Five working days
Specimen retention: 10 days
For any information, contact the National Center for Cancer Care and Research (NCCCR) laboratory on (+974) 44397751/44397745
|
|
|
