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Test ID: ROS1 FFPE FISH Testing
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ROS1 FFPE FISH Testing
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This test identifies the involvement of c-ros oncogene 1 (ROS1) rearrangement.
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Method name and description
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Interphase Fluorescence In situ Hybridization (iFISH) study.
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Clinical information
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This test identifies the involvement of c-ros oncogene 1 (ROS1) gene rearrangement occurring in a small subset of non-small cell lung cancers (NSCLC), lung adenocarcinomas.
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Specimen type / Specimen volume / Specimen container
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Specimen Type: Tissue Block/ Slide
Container/Tube: Slides from Tissue block
Specimen Volume: 1stained H&E slide - 4 unstained slides.
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Storage and transport instructions
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Transport : Ambient
Sample receiving : Sunday-Wednesday 7:00am-3:00PM
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Specimen Rejection Criteria
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Consistent with Diagnostic Genomic Division policies.
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Factors affecting test performance and result interpretation
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A positive result is reported when there is a rearrangement of the ROS1 locus above the normal cutoff for the probe set. The c-ros oncogene 1 (ROS1) locus and a tumor may demonstrate to respond to molecularly targeted therapy.
The results will be correlated with other genetic, pathological and Clinical interpretation.
Rearrangement detection is only limited to ROS1 probe region, any chromosomal alteration outside this region cannot be detected.
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Turnaround time / Days and times test performed / Specimen retention time
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