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Test ID: Hairy Cell Leukemia panel by FISH
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Hairy Cell Leukemia panel by FISH
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Hairy Cell Leukemia panel by FISH
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Method name and description
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Interphase Fluorescence In Situ Hybridization (I-FISH) study.
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Clinical information
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This test is used for identifying a neoplastic clone in patients with Hairy cell leukemia (HCL) and following the response to therapy. Recognizing patients with 11; 14 translocations who have a leukemic stage of HCL.
Identifying patients with a typical HCL/CLL or other forms of lymphoma related translocation between IGH/CCND1 and CEP12, TP53, deletion or other accomplice genes.
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Specimen type / Specimen volume / Specimen container
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1. Specimen Type: Blood/Leukemic Blood:
Container/Tube: Green top (sodium heparin)
Specimen Volume: 2-6 mL (Varies depending on the WBC-Count).
(Adult - 3-6 mL ,Child - 2 mL, Infant - 2 mL)
2. Specimen Type: Bone marrow:
Container/Tube: Bone Marrow Transport Media
Specimen Volume: 1-3 mL (Varies depending on the WBC-Count).
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Collection instructions / Special Precautions / Timing of collection
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Sunday-Wednesday 7:00 -15:00
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Storage and transport instructions
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Specimen Rejection Criteria
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Consistent with Diagnostic Genomic Division policies.
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Factors affecting test performance and result interpretation
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Hairy Cell Leukemia (HCL) could be a low-grade B-cell lymphoproliferative disease that ordinarily presents with cytopenias, splenomegaly, and diffuse bone marrow Infiltration.
There have been few cases of findings of HCL observed as lymphomas in extra-nodal locations, such as soft tissues and bones without circulating leukemic cells, splenomegaly, or iliac crest bone marrow involvement.
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Turnaround time / Days and times test performed / Specimen retention time
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