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Test ID: Glucose-6-phosphate dehydrogenase (quantitative)
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Glucose-6-phosphate dehydrogenase (quantitative)
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Glucose-6-phosphate dehydrogenase (quantitative)
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Useful For
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The determination of potential glucose-6-phosphate dehydrogenase deficiency
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Method name and description
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Clinical information
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Glucose-6-phosphate dehydrogenase is an enzyme of the pentose phosphate pathway that facilitates the regeneration of reduced glutathione, an important cellular antioxidant. A deficieny of this enzyme impairs the cellular ability to produce reduced glutathione, resulting in increased oxidative damage, and increased red cell destruction (haemolytic anaemia).
Glucose-6-phosphate dehydrogenase deficiency is a common cause of neonatal jaundice.
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Specimen type / Specimen volume / Specimen container
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Specimen type: Blood.
Specimen volume: 2-5 mL blood.
Specimen container: EDTA tube.
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Relevant clinical information to be provided
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Presenting clinical signs and symptoms
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Storage and transport instructions
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Blood samples can be transported at ambiant temperature as quickly as possible.
Blood samples stored for up to 7 days at 2-8°C.
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Specimen Rejection Criteria
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Insufficient blood sample volume.
Clotted blood sample.
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Biological reference intervals and clinical decision values
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Female newborn (0-30 days): 344 - 591 mU/10⁹RBC.
Male newborn (0 - 30 days): 339 - 500 mU/10⁹RBC.
Female adult (31 days - 150 years): 192 - 279 mU/10⁹RBC.
Male adult (31 days - 150 years): 191 - 327 mU/10⁹RBC.
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Factors affecting test performance and result interpretation
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Recent blood transfusion can cause misleading results.
Intravascular haemolysis can lead to an increase in glucose-6-phosphate dehydrogenase levels.
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Turnaround time / Days and times test performed / Specimen retention time
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Turnaround time: Two working days
Time test performed: Daily
Specimen retention time: 7 days
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