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Test ID: B-Cell Lymphoma Panel by FISH
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B-Cell Lymphoma Panel by FISH
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B-Cell Lymphoma Panel for hemato-oncology samples by FISH test
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Useful For
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The FISH panel is outlined to distinguish the most common, and/or prognostically-significant abnormalities in B-Cell Lymphoma, this may help in judging between DLBCL and other lymphomas (Swerdlow et al. 2008), as well as revealing ‘double hit’ lymphomas (Aukema et 2011).
FISH studies are valuable adjuncts to total chromosome studies, especially when taken after an abnormal clone, evaluating relapse and progression, or when a sample is insufficient for chromosomal examination.
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Method name and description
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Interphase Fluorescence In Situ Hybridization (I-FISH) study
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Reporting name
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B-Cell Lymphoma Panel by FISH
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Specimen type / Specimen volume / Specimen container
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Specimen Type: Blood/Leukemic Blood
Container/Tube: Green top (sodium heparin)
Specimen Volume: 2-6 mL (Varies depending on the WBC-Count).
(Adult - 3-6 mL ,Child - 2 mL, Infant - 2 mL)
Specimen Type: Bone marrow
Container/Tube: Bone Marrow Transport Media
Specimen Volume: 1-3 mL (Varies depending on the WBC-Count).
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Collection instructions / Special Precautions / Timing of collection
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Sunday-Wednesday 7:00 - 14:00
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Storage and transport instructions
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Specimen Rejection Criteria
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Consistent with Diagnostic Genomic Division policies.
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Factors affecting test performance and result interpretation
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This test panel identifies a set of particular structural chromosome anomalies commonly associated with B-cell Lymphoma, using the desired probes Eg: MYC, IGH/BCL2, IGH/CCND1 and BCL6 for corresponding chromosomes 3q27, 8q24, t(11;14)(q13;q32) and t(14;18)(q32;q21).
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Turnaround time / Days and times test performed / Specimen retention time
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