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Test ID: Lactic Acid CSF
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Lactic Acid CSF
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Useful For
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Differentiation of viral meningitis from bacterial meningitis.
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Method name and description
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Colorimetric assay.
L‑lactate is oxidized to pyruvate by the specific enzyme lactate oxidase (LOD). Peroxidase (POD) is used to generate a colored dye using the hydrogen peroxide generated in the first reaction.
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Clinical information
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Lactate levels in cerebrospinal fluid are increased in bacterial meningitis. Increased CSF levels also occur in hypocapnia, hydrocephalus, brain abscesses, cerebral ischemia and any clinical condition associated with reduced oxygenation of the brain and/or increased intracranial pressure.
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Specimen type / Specimen volume / Specimen container
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Specimen type: CSF
Minimum volume of sample: 1 mL
Specimen Container: Sterile container
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Storage and transport instructions
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Storage: 3 hours at 15 – 25°C
24 hours at 2 – 8°C
2 months at ‑15 to -25°C
Transport: 2-25°C
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Specimen Rejection Criteria
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Insufficient sample and wrong collection container.
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Biological reference intervals and clinical decision values
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Patient Sex
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Age Range
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Range (mmol/L)
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Female/Male
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0 M
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to
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2 D
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1.1 - 6.7
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Female/Male
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2 D
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to
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10 D
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1.1 - 4.4
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Female/Male
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10 D
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to
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18 Y
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1.1 - 2.8
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Female/Male
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>18 Y
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1.1- 2.4
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Turnaround time / Days and times test performed / Specimen retention time
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Daily (24/7)
Turn-around time:
STAT: 1 hour
Routine: One working day
Specimen Retention: 4 days
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