Professor Felipe Prosper MD, PhD
Professor, Head of the Hematology and Cell Therapy Department, University of Navarra
Understanding the Role of Epigenomics in Hematological Malignancies
Professor Prosper graduated from the University of Navarra in 1989. After his residency and PhD he completed his fellowship and postdoctoral training at the University of Minnesota. He then relocated to the Clinica Universidad de Navarra in 2001, here he was responsible for the development of the cell therapy program. He became Head of Hematology and Cell Therapy in 2003 and Director of the programs of Hematology and Cell Therapy at the Center for Applied Medical Research at the University of Navarra in 2012.
Felipe’s principal research interest and key discoveries have been focused on several specific areas
- Understanding epigenetic changes present in patients with hematological malignancies, mainly multiple myeloma and leukemia-MDS. During his research Prof Prosper identified changes in gene methylation, expression of microRNAs and chromatin modifications that are associated with prognosis and treatment response
- Identification of new epigenetic targets and design of new molecules: based on the analysis of epigenetic and epigenomic changes in patients with hematological neoplasms he has validated new targets and signal transduction pathways involved in the pathogenesis of the disease and generated new chemical compounds that target epigenetic enzymes.
- Stem cell biology and stem cell therapy for human diseases: Prof Prosper’s group has been working on the potential of stem cells as therapeutics for a variety of applications including cardiac regeneration and orthopedic diseases
- Clinical trials in patients with multiple myeloma and leukemia-MDS
Professor Prosper has published more than 240 peer review articles in top journals including New England Journal of Medicine, Nature Genetics, Blood, Journal of Clinical Oncology, Journal of Clinical Investigation, Leukemia, Genome Research or Oncogene among others with an H-factor of 52 and over 9000 citations and has given more than 300 lectures. His laboratory is funded through national and international grants including competitive programs such as IMF, European Union (FP6, FP7 and H2020), Spanish Ministry of Health and Ministry of Science and has obtained more than 50 grants. He has received multiple awards and prizes and has mentored over 30 PhD students and postdocs during his career.
