Dr. Shahab Uddin Khan - Head, Molecular Pathophysiology Core Facility
Dr. Shahab Uddin Khan is the Head of the Molecular Pathophysiology Core and a Senior Academic Scientist with the Dermatology Institute. He is also an Adjunct Professor at the Laboratory of Animal Research Center (LARC), Qatar University.
Dr. Khan achieved his PhD in Biochemistry from Aligarh Muslim University, India in 1989. Dr. Khan joined Ohio State University, USA for two years (1989-1991) as a postdoctoral fellow followed by Loyola University of Chicago, Illinois, USA, (1991-1995) as a fellowship under the Molecular Biology Program. In 1996, he joined the University of Illinois at Chicago as a Research Assistant Professor in the Department of Medicine. In 2001, he joined the University of Chicago as Research Associate Professor and in 2003, he joined King Faisal Specialist Hospital & Research Centre, Riyadh, KSA as a Senior Scientist and Deputy Director of the Human Cancer Genomic Program.
The primary research interest of Dr. Shahab is to identify dysregulated molecular signaling involved in survival and proliferation of malignant cells. He is currently a member of several international scientific societies and an active member of the editorial board of various journals such Leukemia Lymphoma, PLOS One, Oncology and several others. He has been the recepient of many research grants from various organizations such as NIH (USA), American Cancer Society and Hamad Medical Corporation (Qatar).
Dr Khan has published over 230 peer-reviewed articles in high impact factor journals with a H-index of 64 and i10-index 174 and was among the top 2% publishing scientists worldwide in 2020.
Select Publications:
Khan AQ, Mohamed EN, Hakeem I, Nazeer A, Kuttikrishnan S, Prabhu KS, Nawaz Z, Ahmad A. Zayed H, Uddin S. Sanguinarine induces apoptosis in papillary thyroid cancer Frontiers Oncol; 9:285, 2019.
Khan AQ, Ahmed EA, Elareer NR, Prabhu KS, Siveen KS, Kulinski M, Ahmad A, Steinhoff M, Uddin S. Curcumin-mediated apoptotic cell death in papillary thyroid cancer and cancer stem-like cells through targeting of JAK/STAT3 signaling pathway. Int J Mol Sci;21. pii: E438, 2020
Kuttikrishnan S, Siveen KS, Prabhu KS, Khan AQ, Ahmed EI, Akhtar S, Ali TA, Merhi M, Dermime S, Steinhoff M, Uddin S. Curcumin induces mitochondrial apoptotic cell death via inhibition of PI3-Kinase/AKT pathway in B-precursor acute lymphoblastic leukemia. Front in Oncol ;9: 484, 2019.
Akhtar S, Achkar IW, Siveen KS, Kuttikrishnan S, Prabhu KS, Khan AQ, Ahmed EI, Sahir F,, Jerobin J, Raza A, Merhi M, Elsabah HM, Taha R, Omri HE, Zayed H, Dermime S, Steinhoff M, Uddin S. Sanguinarine induces apoptosis pathway in multiple myeloma cell lines via inhibition of the JaK2/STAT3 signaling. Frontiers Oncol; 9:285, 2019.
Prabhu KS, Siveen KS, Kuttikrishnan S, Jochebeth A, Ali TA, Elareer NR, Iskandarani A, Quaiyoom Khan A, Merhi M, Dermime S, El-Elimat T, Oberlies NH, Alali FQ, Steinhoff M, Uddin S. Greensporone A, a Fungal Secondary Metabolite Suppressed Constitutively Activated AKT via ROS Generation and Induced Apoptosis in Leukemic Cell Lines. Biomolecules. 9.126; 2019.
Media and Press Release
ORCID: 0000-0003-1886-6710
Google Scholar: https://scholar.google.com/citations?user=cTJQRLkAAAAJ
Research Gate: https://www.researchgate.net/profile/Shahab_Uddin_PhD/scores